Cellkey Inc, South Korea
👨🎓Profile
🎓 Early Academic Pursuits
Dr. Kwang Hoe Kim’s academic journey began at Chungnam National University, South Korea, where he completed his Bachelor’s degree in Chemistry in March 2009. This foundational training in the sciences paved the way for his later research. In 2010, he advanced to the Graduate School of Analytical Science and Technology at the same institution, earning a Master’s degree (M.S.) in February 2012. Under the guidance of Professor Jong Shin Yoo, he developed key skills in mass spectrometry and glycoproteomics. He continued to build on this expertise, earning his Ph.D. in 2019, further honing his skills in mass spectrometry and biomarker discovery.
🧪 Professional Endeavors
Dr. Kim’s professional journey has been marked by his leadership in advancing the field of bioanalytical research, particularly in oncology. In January 2021, he took on the role of Head of the Bio R&D Center at CellKey, where he focuses on the development of diagnostic biomarkers for cancer detection and management. His work also includes advancing companion diagnostics in immuno-oncology, leveraging mass spectrometry for clinical applications. Prior to this, he worked as a Postdoctoral Researcher at the Korea Basic Science Institute, where he made significant contributions to the detection of hepatocellular carcinoma, a leading form of liver cancer.
🔬 Contributions and Research Focus
Dr. Kim’s research has been deeply focused on the application of mass spectrometry for cancer diagnosis and biomarker discovery. His work includes developing liquid chromatography-mass spectrometry-based methods to identify cancer-associated proteins and glycoproteins. At the Research Center for Bioconvergence Analysis, he worked on developing a multi-biomarker panel for hepatocellular carcinoma detection, using mass spectrometry to enhance diagnostic sensitivity. His work in optimizing immunoprecipitation/targeted mass spectrometry methods has made significant contributions to the analytical sensitivity of peptide and glycopeptide analyses.
🌍 Impact and Influence
Dr. Kim’s work has had a notable impact on both the scientific community and clinical applications. His research into mass spectrometry-based diagnostic methods has helped pave the way for more accurate and sensitive detection of cancer biomarkers, particularly in liver cancer. His development of multi-biomarker panels for cancer detection is a key step forward in precision medicine, which promises to enhance personalized treatment strategies for cancer patients. The clinical applications of his research in immuno-oncology also offer promise in the future of cancer care.
📚 Academic Citations
Dr. Kim’s research has earned recognition in the scientific community, with several published papers and citations highlighting his contributions to mass spectrometry and cancer biomarker research. His work on aberrant glycoproteins in colorectal cancer and hepatocellular carcinoma has been instrumental in advancing the understanding of cancer biomarkers, leading to increased citations in the fields of oncology and analytical chemistry.
🛠️ Technical Skills
Dr. Kim possesses a wide range of technical skills, particularly in the area of mass spectrometry. He is an expert in developing and applying various mass spectrometry techniques such as multiple reaction monitoring (MRM), parallel reaction monitoring (PRM), and high-resolution mass spectrometry using MALDI MS and FT-ICR. Additionally, he has extensive experience in protein quantification through immunoprecipitation and targeted mass spectrometry, particularly for low-abundance proteins. His technical expertise extends to the development of methods for high-throughput peptide and glycopeptide analysis.
👨🏫 Teaching Experience
Throughout his career, Dr. Kim has been actively involved in mentoring and educating the next generation of scientists. While pursuing his graduate studies, he worked as a research assistant and fellow, helping to guide students in laboratory techniques and research methodologies. His role as a leader in the Bio R&D Center at CellKey also involves sharing his expertise with younger researchers and fostering a collaborative environment for innovation in cancer diagnostics.
🌱 Legacy and Future Contributions
Looking to the future, Dr. Kim’s work promises to leave a lasting legacy in the fields of mass spectrometry and cancer diagnostics. His continued efforts to refine diagnostic biomarkers and improve detection methods are expected to contribute significantly to the fields of personalized medicine and immuno-oncology. As he expands his research into new areas, his contributions will likely inspire new diagnostic tools and clinical applications, shaping the future of cancer research and treatment.
🔮 Future Goals
Dr. Kim’s future goals include the further development of advanced diagnostics for early cancer detection and the continuous improvement of biomarker panels. With the evolving field of immuno-oncology, he plans to work on improving companion diagnostics, focusing on the use of mass spectrometry to assess tumor microenvironments and treatment responses. His dedication to advancing the science of cancer biomarkers positions him at the forefront of precision medicine, with the potential to greatly impact clinical practices.
📖Notable Publications
LC-MS/MS-Based Site-Specific N-Glycosylation Analysis of VEGFR-IgG Fusion Protein for Sialylation Assessment Across IEF Fractions
- Authors: Kim, K. H., Ji, E. S., Lee, J. Y., Song, J. H., & Ahn, Y. H.
Journal: Molecules
Year: 2024
Measuring fucosylated alpha‐fetoprotein in hepatocellular carcinoma: A comparison of μTAS and parallel reaction monitoring
- Authors: Kim, K. H., Lee, S. Y., Baek, J. H., Lee, S. Y., Kim, J. Y., & Yoo, J. S.
Journal: PROTEOMICS–Clinical Applications
Year: 2021
Absolute Quantification of N-Glycosylation of Alpha-Fetoprotein Using Parallel Reaction Monitoring with Stable Isotope-Labeled N-Glycopeptide as an Internal Standard
- Authors: Kim, K. H., Lee, S. Y., Kim, D. G., Lee, S. Y., Kim, J. Y., & Yoo, J. S.
Journal: Analytical Chemistry
Year: 2020
BMDMSNP: A comprehensive ESI-MS/MS spectral library of natural compounds
- Authors: Lee, S., Hwang, S., Seo, M., Shin, K. B., Kim, K. H., Park, G. W., & No, K. T.
Journal: Phytochemistry
Year: 2020
Mass spectrometry analysis of glycoprotein biomarkers in human blood of hepatocellular carcinoma
- Authors: Kim, K. H., Kim, J. Y., & Yoo, J. S.
Journal: Expert Review of Proteomics
Year: 2019
Parallel reaction monitoring with multiplex immunoprecipitation of N-glycoproteins in human serum for detection of hepatocellular carcinoma
- Authors: Kim, K. H., Park, G. W., Jeong, J. E., Ji, E. S., An, H. J., Kim, J. Y., & Yoo, J. S.
Journal: Analytical and Bioanalytical Chemistry
Year: 2019